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. 2019 Jul 26;9:10890. doi: 10.1038/s41598-019-46690-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Multiplex IP-FCM detects more complexes in NP-40 or Triton Conditions: (A) Workflow. (B) Unsupervised hierarchical clustering of all conditions. Numbers at the branch points show the approximately unbiased (AU) p value calculated by multiscale bootstrap resampling; clusters with AU greater than 95 are boxed in red. (C) PCA of all conditions. Note DOC and NP-40/Triton conditions separated by both hierarchical clustering and PCA. (D) Heatmap of 6 interactions identified as significantly different between NP-40 and Triton conditions by ANC ∩ CNA analysis. (E) Heatmap of 112 interactions identified as significantly different between either DOC vs. NP-40 or DOC vs. Triton conditions. Note that hierarchical clustering again separated NP-40 and Triton conditions from DOC. (F) QMI map of the all interactions that exhibited greater than a >2-fold difference between DOC and NP-40/Triton conditions. The thickness and color of lines connecting protein nodes indicate the direction and magnitude of the fold change with interactions that are higher in NP-40/Triton colored red and interactions that are higher in DOC colored blue.