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. 2019 Jul 26;9:10864. doi: 10.1038/s41598-019-47391-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptional profiling of IFP-MSC and BM-MSC pre- and post-TI and TIC priming. Transcriptional assessment of IFP-MSC and BM-MSC pre and post TI (A) and TIC (B) priming, showing similar profiles between both methods but with statistical differences (p < 0.05) between MSC types in HGF, IL-6, IL-8, ICAM-1 and G-CSF gene expression (asterisk *). Nevertheless, the trends are similar, including a low IL-6/IL-8 ratio. All experiments (n = 3) were performed independently (3 different donors) and data are presented as scatter plots with mean ± SD. All shown genes have overall (both MSC) statistically significant (p < 0.05) differences compared with naïve cells (set up to 1 - dotted line - to calculate the fold change). One-way ANOVA for multiple comparisons was used for statistical analysis.