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. 2019 Jul 26;9:10864. doi: 10.1038/s41598-019-47391-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IFP-MSC and BM-MSC secretory profiling pre- and post-TI and TIC priming. (A) Growth factors and cytokines secretion in all groups, showing overall quantified fold signal (TI and TIC compared to naïve). (B,D) Heat maps of the growth factor (B) and inflammation-related cytokines (D) secretory profile of naïve, TI and TIC primed IFP- and BM-MSCs, showing only proteins with statistically significant changes in C and E, respectively. Heat maps colours are assigned according to a molecule concentration relative scale, from 0 to 10,000. All experiments (n = 2) were performed independently (2 different donors) and data are presented as floating bars with minimum, maximum and mean. Paired and unpaired t tests and one-way ANOVA for multiple comparisons were used for statistical analysis *p < 0.05.