Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 26;9:10864. doi: 10.1038/s41598-019-47391-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Protein interactomes of IFP-MSC and BM-MSC secretory profiling pre- and post-TI and TIC priming. (A) STRING analysis of those proteins with statistical differences between naïve and TI-/TIC- priming conditions (total of 46) was performed using all available interaction sources and 0.4 as a confidence interaction score. K-means algorithm resulted into firm clustering of the differentially expressed factors into 3 groups (different colours) indicating high protein interaction within each group. (B) Venn diagram showing shared proteins among the groups, with AR, ICAM-1, IP-10, MCP-2, TNF-α, RANTES and IFN-γ present in both MSC types and in inflammatory and pro-fibrotic conditions. Table shows the number of proteins shared by different groups and conditions. (C) Biological processes and KEGG/reactome pathways analyses revealed different type and number of proteins affected post-TI and -TIC priming for both IFP-MSC and BM-MSC. Graph percentages represent the number of proteins involved in a specific pathway/function, related to the total amount of proteins differentially expressed between naïve and TI-/TIC-priming conditions.