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. 2019 Jul 26;9:10864. doi: 10.1038/s41598-019-47391-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Substance P immuno-quantification. (A) ELISA-based quantification of endogenous and exogenously-added SP to naïve (N), TI- and TIC-primed IFP-MSC (blue) and BM-MSC (red) cells and supernatant groups, with or without previous CD10 inhibition with thiorphan (thio). Wells with only exogenously-added SP to medium (Exo SP - green) were used as baseline to assess the degradative effects of cells and supernatants. A diagram represents the source of the samples obtained for the measurements. (B) CD10 immunolocalization in naïve, TI and TIC-primed IFP-MSC and BM-MSC. Data from three (n = 3) independent experiments (3 different donors) are presented as scatter plots with mean ± SD. *p < 0.05 between +/− thiorphan for each condition; ^#p < 0.05 with respect to naïve (N) IFP-MSC or supernatant; ^&p < 0.05 with respect to naïve (N) BM-MSC or supernatant. Paired and unpaired t tests were used for statistical analysis.