Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 26;2:276. doi: 10.1038/s42003-019-0521-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — A proposed mechanism (developed with integrated multi-omic analysis of transgenic animal models) showing the relationship between tissue omega-6/omega-3 fatty acid imbalance and the development of chronic disease. a To assemble the overall correlations among our data (n = 6/group), we performed correlation network analysis (Spearman’s non-parametric rank correlation coefficient). Each node was colored according to the data type and sized based on the betweenness centrality, which quantifies the influence of a node in connecting other nodes in a network. Edges (lines) represent statistically significant correlations, and are colored light black for positive and blue for negative correlations. Please refer panel b for abbreviations. b PCA (correlation type) analysis was performed on selected key parameters (n = 6/group), including the genotypes, gut microbiota, fecal and serum metabolites, and markers of metabolic disorders. c Diagram illustrating our proposed mechanism of tissue omega-6/omega-3 fatty acid imbalance leading to the development of chronic disease. Elevated tissue omega-6 PUFA status and an increased tissue n-6/n-3 fatty acid ratio alters gut microbiota and gut microbial functional pathways, which in turn adversely influence fecal metabolites production and eventually microbiota-derived serum metabolites levels. These alterations plus adverse changes in the levels of serum non-microbiota-derived metabolites directly influenced by the elevated tissue n-6/n-3 fatty acid ratio lead to increased intestinal permeability, development of metabolic endotoxemia and chronic low-grade inflammation, resulting in the occurrence of chronic disease (metabolic syndrome and cancer)