Table 2:
Replicated gene transcripts (n=31) associated with total IgE using two different statistical approaches in two distinct cohorts with asthma: GACRS and CAMP
| Gene Symbol | Gene Name | Chr | GACRS P-Value |
CAMP P-Value |
Sig. adjusted for ICS | Linked with eosinophils |
||
|---|---|---|---|---|---|---|---|---|
| Esnault (37) | Nakajima(38) | MSigDB(29) | ||||||
| PRSS33 | protease, serine, 33 | 16 | 2.8×10−9 | 2.4×10−10 | ■ | ● | ||
| OLIG2 | oligodendrocyte lineage transcription factor 2 | 21 | 1.7×10−8 | 2.3×10−12 | ■ | ● | ||
| TFF3 | trefoil factor 3 (intestinal) | 21 | 2.4×10−8 | 6.7×10−13 | ■ | ● | ||
| CLC* | Charcot-Leyden crystal protein | 19 | 3.8×10−8 | 4.0×10−9 | ■ | ● | ● | |
| CCL23 | chemokine (C-C motif) ligand 23; macrophage inflammatory protein 1-alpha (MIP-1-alpha) | 17 | 1.5×10−7 | 3.0×10−10 | ■ | ● | ● | |
| EMR4P | adhesion G protein-coupled receptor E4, pseudogene | 19 | 1.5×10−7 | 7.1×10−6 | ■ | ● | ||
| OLIG1 | oligodendrocyte transcription factor 1 | 21 | 1.5×10−7 | 7.8×10−7 | ■ | ● | ||
| GPR44* | prostaglandin D2 receptor 2, G protein-coupled receptor 44, (aka CRTH2) | 11 | 2.0×10−7 | 2.1×10−8 | ■ | ● | ● | |
| FLJ43093 | Unknown | 6 | 2.5×10−7 | 2.0×10−8 | ■ | |||
| CEBPE | CCAAT/enhancer binding protein (C/EBP), epsilon | 14 | 2.7×10−7 | 2.6×10−13 | ■ | ● | ||
| PYROXD2 | pyridine nucleotide-disulphide oxidoreductase domain 2 (PYROXD2) | 10 | 3.3×10−7 | 3.8×10−10 | ■ | ● | ||
| SORD2 | sorbitol dehydrogenase | 15 | 1.5×10−6 | 4.9×10−5 | ■ | |||
| SIGLEC8* | sialic acid binding Ig-like lectin 8 | 19 | 1.6×10−6 | 5.0×10−9 | ■ | ● | ||
| PIK3R6* | phosphoinositide-3-kinase, regulatory unit 6 | 17 | 2.9×10−6 | 2.0×10−8 | ■ | ● | ||
| LGALS12 | galectin 12 | 11 | 6.1×10−6 | 3.7×10−4 | ■ | ● | ||
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 6 | 8.7×10−6 | 1.8×10−3 | ■ | |||
| CCR3* | chemokine (C-C motif) receptor 3 | 3 | 1.8×10−5 | 9.2×10−5 | ■ | ● | ● | |
| IL5RA* | interleukin 5 receptor, alpha | 3 | 3.5×10−5 | 0.020 | ■ | ● | ● | |
| SMPD3 | sphingomyelin phosphodiesterase 3, neutral membrane | 16 | 5.6×10−5 | 2.2×10−6 | ■ | ● | ||
| INPP1 | inositol polyphosphate-1-phosphatase | 2 | 1.5×10−4 | 6.4×10−5 | ■ | |||
| EMR1 | adhesion G protein-coupled receptor E1 (alias ADGRE1) | 19 | 2.5×10−4 | 5.5×10−3 | ■ | ● | ||
| ACOT11 | acyl-CoA thioesterase 11 | 1 | 2.6×10−4 | 2.1×10−4 | ■ | |||
| CAMK1 | calcium/calmodulin-dependent protein kinase I | 3 | 3.0×10−4 | 6.8×10−5 | ■ | ● | ● | |
| VSTM1 | V-set & transmembrane domain containing 1 | 19 | 4.6×10−4 | 1.9×10−6 | ■ | ● | ||
| RNF14 | ring finger protein 14 | 5 | 4.6×10−4 | 3.1×10−5 | ■ | |||
| SPNS3 | spinster homolog 3 (Drosophila) | 17 | 6.2×10−4 | 6.6×10−9 | ■ | ● | ||
| ZBTB42 | zinc finger and BTB domain containing 42 | 14 | 7.5×10−4 | 2.7×10−8 | ■ | |||
| IDO1* | indoleamine 2,3-dioxygenase 1 (aka INDO) | 8 | 1.1×10−3 | 2.4×10−10 | ■ | ● | ● | |
| LOC642639 | Unknown | 9 | 1.2×10−3 | 1.7×10−3 | ■ | |||
| LTC4S* | leukotriene C4 synthase | 5 | 2.5×10−3 | 6.9×10−6 | ■ | ● | ||
| CYP4F12 | cytochrome P450, family 4, subfamily F, polypeptide 12 | 19 | 4.2×10−3 | 2.0×10−5 | ■ | ● | ||
*
Known association with IgE.
●
known association with eosinophils.
GACRS=Genetics of Asthma in Costa Rica Study
CAMP=Childhood Asthma Management Program
MSigDB=Molecular Signature Database.
■
Significant in both cohorts after adjustment for recent inhaled corticosteroid (ICS) use.