Table 3;
Gene-ontology defined biological processes associated with total IgE using two different statistical approaches in two different cohorts: GACRS and CAMP cohorts.
| GO biological process | # Genes in GO Group | Differential Gene Expression | WGCNA | ||||
|---|---|---|---|---|---|---|---|
| GACRS & CAMP | GACRS | CAMP | |||||
| Fold Enrichment | Raw P value | Fold Enrichment | Raw P value | Fold Enrichment | Raw P value | ||
| regulation of leukocyte mediated immunity (GO:0002703): CLC, PIK3R6 | 167 | 9.7 | 0.0038 | 6.3 | 0.0014 | 10.5 | 0.0030 |
| regulation of leukocyte proliferation (GO:0070663) : IDO1, CLC | 219 | 7.4 | 0.0080 | 5.8 | 0.0007 | 8.0 | 0.0064 |
| regulation of lymphocyte mediated immunity (GO:0002706): CLC, PIK3R6 | 126 | 12.9 | 0.0017 | 6.7 | 0.0034 | 13.9 | 0.0014 |
| regulation of lymphocyte proliferation (GO:0050670) : IDO1, CLC | 210 | 7.7 | 0.0071 | 6.0 | 0.0006 | 8.4 | 0.0057 |
| regulation of mononuclear cell proliferation (GO:0032944) : IDO1, CLC | 211 | 7.7 | 0.0072 | 6.0 | 0.0006 | 8.3 | 0.0058 |
| regulation of T cell tolerance induction (GO:0002664): IDO1, CLC | 12 | 89.9 | 0.0003 | 35.1 | 0.0019 | 97.4 | 0.0003 |
| regulation of tolerance induction (GO:0002643): IDO1, CLC | 18 | 60.0 | 0.0006 | 23.4 | 0.0040 | 64.9 | 0.0005 |
| neuron fate commitment (GO:0048663): OLIG1, OLIG2 | 70 | 15.4 | 0.0079 | 12.0 | 0.0004 | 16.7 | 0.0067 |
| oligodendrocyte differentiation (GO:0048709) : OLIG1, OLIG2 | 65 | 16.6 | 0.0068 | 13.0 | 0.0003 | 27.0 | 0.0002 |
| positive regulation of glial cell differentiation (GO:0045687): OLIG2, CLC | 33 | 32.7 | 0.0019 | 19.1 | 0.0007 | 35.4 | 0.0016 |
| positive regulation of gliogenesis (GO:0014015) : OLIG2, CLC | 51 | 31.7 | 0.0001 | 16.5 | 0.0001 | 22.9 | 0.0037 |
| regulation of glial cell differentiation (GO:0045685) : OLIG2, CLC | 59 | 18.3 | 0.0057 | 14.3 | 0.0002 | 19.8 | 0.0049 |