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Pharmacological inhibition of the protease calpain protects against DOX-induced atrophy of the rodent (A) diaphragm and locomotor skeletal muscle fibers (i.e., (B) plantaris and (C) soleus). See text for details. Data are from Min et al. [59]. Key: CON = control; DOX = doxorubicin treatment; CON + SJA= control animals treated with the calpain inhibitor SJA; DOX + SS31= animals treated with both DOX and SJA; * = different (P<0.05) from all other groups; † = different (P<0.05) from CON.
