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. 2019 Jul 24;35(6):341–349. doi: 10.1089/jop.2019.0020

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© Lionel Sebbag et al. 2019; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 4. — Bar charts depicting mean + standard deviation of area under the tear concentration-time curve from time zero to time of last measurable concentration (AUC_last). Data for tear concentrations of prednisone (A) and prednisolone (B) are shown for all 4 oral doses of prednisone (0.5–4.0 mg/kg) in eyes with experimentally induced mild conjunctivitis (light gray) or severe conjunctivitis (dark gray). Within the same dose, statistical comparisons between mild and severe conjunctivitis (t test) are described with P values above the plots, and statistical significance (P < 0.05) is depicted with an asterisk (*).