Table 1.
Mean ± Standard Deviation of the Maximal Concentration (Cmax) and Time to Reach Cmax (Tmax) for Prednisone and Prednisolone in Control and Conjunctivitis Eyes
| Prednisone | Prednisolone | |||
|---|---|---|---|---|
| Cmax (ng/mL) | Tmax (min) | Cmax (ng/mL) | Tmax (min) | |
| Dose 1 (0.5 mg/kg) | ||||
| Control | 23.2 ± 13.4 | 77.5 ± 89.7 | 19.2 ± 19.5 | 115.0 ± 99.3 |
| Conjunctivitis | 55.1 ± 68.1 | 87.5 ± 85.1 | 22.4 ± 26.7 | 130.0 ± 86.3 |
| Dose 2 (1.0 mg/kg) | ||||
| Control | 47.7 ± 26.4 | 140.0 ± 187.3 | 29.2 ± 24.9 | 215.0 ± 257.0 |
| Conjunctivitis | 48.1 ± 25.5 | 87.5 ± 85.1 | 37.1 ± 32.1 | 145.0 ± 166.9 |
| Dose 3 (2.0 mg/kg) | ||||
| Control | 91.7 ± 74.7 | 127.5 ± 97.6 | 75.3 ± 64.3 | 420.0 ± 211.3# |
| Conjunctivitis | 137.2 ± 115.5 | 65.0 ± 22.6 | 62.7 ± 31.3 | 320.0 ± 196.0 |
| Dose 4 (4.0 mg/kg) | ||||
| Control | 116 ± 67.2# | 127.5 ± 93.8 | 123.6 ± 47.8#,† | 160.0 ± 92.3 |
| Conjunctivitis | 204.3 ± 173.5 | 120.0 ± 180.7 | 120.0 ± 38.1#,†,‡ | 160.0 ± 92.3 |
Within the same drug dose, comparisons between control and conjunctivitis eyes did not reveal any statistical differences (P > 0.05). Within the same ocular group (control or conjunctivitis), differences among doses are depicted with symbols to demonstrate statistically greater values compared to dose 1 (#), dose 2 (†), and dose 3 (‡).