Figure 6. MiR-190b methylation and proportions of BRCA2-wild-type to mutant allele in BRCA^999del5 carrier tumors.

BRCA2 proportion of 0.5 indicates 1:1 proportions of wt-BRCA2 and 999^del5 alleles, values under 0.5 suggest loss of wt-BRCA2. The proportions are positively correlated with miR-190b methylation (Multivariate linear regression corrected for ER status, age at diagnosis and year of diagnosis, P = 0.008, R² = 0.45, n = 23).