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. 2019 Jul 23;10(45):4630–4639. doi: 10.18632/oncotarget.27050

Figure 2. GREM1 mRNA levels in cell populations and tumour tissue, and correlations with FAP expression and StromalScore.

Figure 2

(A) In GSE39396, which contains data from six fresh colon tumours sorted using fluorescence-activated cell sorting (FACS), fibroblasts contain more GREM1 mRNA than endothelial cells, epithelial cells and leukocytes (all p < 0.0001). (B) In GSE33114, GREM1 mRNA levels are significantly higher in primary tumours compared to CRC stem cells (p < 0.0001) and borderline significant compared to normal tissue (p = 0.0744). (ns non-significant, **** p < 0.0001). (C) Scatterplot (left) showing positive correlation between GREM1 mRNA levels and FAP expression in GSE39582 (Pearson r = 0.7117, p < 0.0001). GREM1 mRNA levels also positively correlated with StromalScore (right; Pearson r = 0.7448, p < 0.0001).