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. 2019 Jul 26;2019(7):CD008873. doi: 10.1002/14651858.CD008873.pub4

Comparison 2. Supplementation with vitamin D + calcium versus placebo or no intervention (no vitamin or minerals).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Pre‐eclampsia (ALL) 4 1174 Risk Ratio (M‐H, Random, 95% CI) 0.50 [0.32, 0.78]
2 Gestational diabetes (ALL) 1 54 Risk Ratio (M‐H, Random, 95% CI) 0.33 [0.01, 7.84]
3 Preterm birth (less than 37 weeks' gestation) (ALL) 5 942 Risk Ratio (M‐H, Random, 95% CI) 1.52 [1.01, 2.28]
4 Low birthweight (less than 2500 g) (ALL) 2 110 Risk Ratio (M‐H, Random, 95% CI) 0.68 [0.10, 4.55]
5 Caesarean section 2 146 Risk Ratio (M‐H, Random, 95% CI) 1.16 [0.87, 1.54]
6 Gestational hypertension 1 59 Risk Ratio (M‐H, Random, 95% CI) 0.26 [0.06, 1.12]
7 Maternal vitamin D concentration at term (25‐hydroxyvitamin D) (nmol/L) (ALL) 1 60 Mean Difference (IV, Random, 95% CI) 12.5 [3.80, 21.20]
8 Birth length (cm) 3 194 Mean Difference (IV, Random, 95% CI) ‐0.07 [‐0.67, 0.52]
9 Head circumference at birth (cm) 3 198 Mean Difference (IV, Random, 95% CI) ‐0.03 [‐0.39, 0.33]
10 Birthweight (g) 3 194 Mean Difference (IV, Random, 95% CI) 42.39 [‐86.96, 171.74]
11 Neonatal death 1 660 Risk Ratio (M‐H, Random, 95% CI) 0.2 [0.01, 4.15]