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. 2019 Jul 26;2019(7):CD008873. doi: 10.1002/14651858.CD008873.pub4

Comparison 3. Supplementation with vitamin D + calcium + other vitamins and minerals versus calcium + other vitamins and minerals (but no vitamin D).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Gestational diabetes (ALL) 1 1298 Risk Ratio (M‐H, Random, 95% CI) 0.42 [0.10, 1.73]
2 Maternal adverse events 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.1 Hypercalcaemia 1 1298 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
2.2 Hypercalciuria 1 1298 Risk Ratio (M‐H, Random, 95% CI) 0.25 [0.02, 3.97]
3 Preterm birth (less than 37 weeks' gestation) (ALL) 1 1298 Risk Ratio (M‐H, Random, 95% CI) 1.04 [0.68, 1.59]
4 Low birthweight (less than 2500 g) (ALL) 1 1298 Risk Ratio (M‐H, Random, 95% CI) 1.12 [0.82, 1.51]
5 Caesarean section 1 1298 Risk Ratio (M‐H, Random, 95% CI) 1.10 [0.95, 1.27]
6 Gestational hypertension 1 1298 Risk Ratio (M‐H, Random, 95% CI) 0.93 [0.31, 2.79]
7 Maternal death (death while pregnant or within 42 days of termination of pregnancy) 1 1300 Risk Ratio (M‐H, Random, 95% CI) 0.25 [0.02, 3.98]
8 Maternal vitamin D concentration at term (25‐hydroxyvitamin D) (nmol/L) (ALL) 1 635 Mean Difference (IV, Random, 95% CI) 75.17 [71.97, 78.37]
9 Birth length (cm) 1 1297 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐0.28, 0.28]
10 Head circumference at birth (cm) 1 1297 Mean Difference (IV, Random, 95% CI) 0.0 [‐0.17, 0.17]
11 Birthweight (g) 1 1297 Mean Difference (IV, Random, 95% CI) ‐7.0 [‐55.95, 41.95]
12 Stillbirth 1 1300 Risk Ratio (M‐H, Random, 95% CI) 0.66 [0.29, 1.46]
13 Neonatal death 1 1298 Risk Ratio (M‐H, Random, 95% CI) 0.69 [0.22, 2.14]