Kaur 1991.
Methods | Randomised controlled trial. | |
Participants | 50 pregnant women with similar socioeconomic conditions in India. | |
Interventions | Participants were randomised into 2 groups: group 1 (n = 25) received orally 2 pharmacological doses of vitamin D˜ (60,000 IU each) in 6th and 7th month of pregnancy; group 2 (n = 25) did not receive any vitamin supplement and served as controls. Health worker cadre: not specified. |
|
Outcomes | Infant: mean birthweight, placental weight and DNA content, total protein and RNA, protein/DNA and RNA/DNA ratios. Laboratory method used for assessment of vitamin D concentrations: not applicable. |
|
Notes |
Source of funding: unknown/unreported. Dates of the study and location: not reported dates, India. Declarations of interest among primary researchers (or state where this information is not reported by the trial authors): not reported. |
|
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Authors only mentioned that women were randomly selected for trial initially. |
Allocation concealment (selection bias) | Unclear risk | The trial did not report the method of concealment. It is assumed that no method was used as one of the groups did not receive any supplementation. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | The trial did not report if it was blinded. It is assumed that it was not blinded to participants as one of the groups did not receive any supplementation. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | There is insufficient information to permit judgement. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | The number lost to follow‐up was not reported in results. |
Selective reporting (reporting bias) | Unclear risk | The total number of participants that completed the study was not specified in results. |
Other bias | Low risk | The study appears to be free of other sources of bias. |