Mazurkevich 2013.
Methods | Randomised control trial. | |
Participants | 72 pregnant women with physiological pregnancy aged 18 to 35 years with low alimentary consumption of calcium (< 600 mg/day) who attended to Moscow State University of medicine and dentistry, department of obstetrics and gynaecology. (Latitude: 55.7500° N, 37.6167° E). | |
Interventions | Participants were randomly assigned to 1 of 2 groups: group 1 (n = 43) received 1250 mg of calcium carbonate and 200 IU of vitamin D (cholecalciferol‐D3) from the second pregnancy trimester until term, in 2 takes a day; group 2 (n = 29) did not receive any treatment and served as controls. Health worker cadre: not specified. |
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Outcomes | Maternal: resistance of uterine arteries, resistance of umbilical arteries, uterine‐placental circulation. Infant: fetal‐placental circulation, intrauterine growth retardation, assessed by dopplerometry. Laboratory method used for assessment of vitamin D concentrations: not applicable. |
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Notes |
Source of funding: unknown/unreported. Dates of the study and location: not reported dates, Moscow, Russia. Declarations of interest among primary researchers (or state where this information is not reported by the trial authors): none declared. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | The trial reported that participants were randomly allocated to the intervention groups but they did not report the method of sequence generation. |
Allocation concealment (selection bias) | Unclear risk | The trial did not report the method of concealment. It is assumed that they did not conceal the allocation as one of the groups did not receive any supplementation. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | The trial did not report if the study was blinded. It is assumed that it was not blinded to participants as one of the groups did not receive any supplementation. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | The trial did not report if research staff was blinded. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | There is insufficient information to permit judgement. |
Selective reporting (reporting bias) | Unclear risk | There is insufficient information to permit judgement. |
Other bias | Low risk | The study appears to be free of other sources of bias. |