TABLE 1.

Criteria for major depressive episode.

CRITERIA
A.	Five (or more) of the following nine symptoms have been present during the same two-week period and represent a change from previous functioning; at least one of the symptoms is either 1) depressed mood or 2) loss of interest or pleasure.
	1.	Depressed mood most of the day, nearly every day, as indicated by either subjective report (e.g., feels sad, empty, hopeless) or observations made by others (e.g., appears tearful).
	2.	Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day (as indicated by either subjective account or observation)
	3.	Significant weight loss when not dieting or weight gain (e.g., a change of more than five percent of body weight in a month), or decrease or increase in appetite nearly every day.
	4.	Insomnia or hypersomnia nearly every day
	5.	Psychomotor agitation or retardation nearly every day (observable by others, not merely subjective feelings of restlessness or being slowed down)
	6.	Fatigue or loss of energy nearly every day
	7.	Feelings of worthlessness or excessive or inappropriate guilt (which might be delusional) nearly every day (not merely self-reproach or guilt about being sick)
	8.	Diminished ability to think or concentrate, or indecisiveness, nearly every day (either by their subjective account or as observed by others)
	9.	Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide
B.	The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.
C.	The episode is not attributable to the direct physiological effects of a substance or to another medical condition.