Table 1:
Study | Hypercapnia threshold * | Actual PaCO2 | Age | FEV1 (% pred.) | Device | Pressures (cm H2O) | Pressure assist | Duration (months) |
---|---|---|---|---|---|---|---|---|
Casanova 2000 | None | 52 ± 8.4 | 66 ± 5 | 30% | Bilevel PAP | 12 / 4 | 8 | 12 |
Clini 2002 | > 50 | 54.8 ± 4.5 | 65 ± 14 | 29% | Bilevel PAP | 14 / 2 | 12 | 24 |
Xiang 2007 | > 55 | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown | 24 |
McEvoy 2009 | > 46 | 53.5 ± 2.4 | 68 ± 1.7 | 24% | Bilevel PAP | 12.9 / 5.1 | 7.8 | 26 |
Struik 2014 | None | 58.5 ± 9.0 | 63.7 ± 8.2 | 25.6% | Bilevel PAP (S/T mode) | 19.2/14.8 | 4.4 | 12 |
Kohnlein 2014 | > 51.9 | 58.1 ± 5.6 | 63.2 ± 8.0 | 26.7% | Home ventilator | 21.6 / 4.8 (back-up rate 16) | 16.8 | 12 |
Zhou 2017 | > 50 | None | 67 ± 7 | 25.5% | Bilevel PAP | 17.8 / 4.2 | 13.6 | 3 |
Murphy 2017 | > 53 | 59 ± 7 | 67 ± 10 | 23.5% | Home ventilator | 24 / 4 (back-up rate 14) | 20 | 12 |
PaCO2 = partial pressure of arterial CO2 level (mmHg); FEV1 = Forced expiratory volume in 1 second; % pred. = Percent predicted; cm H2O = centimeters of water; ± standard deviation; Bilevel PAP = bilevel positive airway pressure.
mmHg of PaCO2