Table 4. Multivariate Cox regression for effect of lactate-clearance on 90-day mortality (derivation cohort).

	Crude		Adjusted model I		Adjusted model II
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Cirrhosis
Δ24Lac per 10%	0.94 (0.92, 0.95)	<0.001	0.93 (0.91, 0.94)	<0.001	0.94 (0.92, 0.97)	<0.001
Categories
Δ24Lac Q1	Ref	Ref	Ref	Ref	Ref	Ref
Δ24Lac Q2	0.73 (0.52, 1.02)	0.066	0.67 (0.48, 0.95)	0.029	0.62 (0.41, 0.95)	0.026
Δ24Lac Q3	0.34 (0.23, 0.50)	<0.001	0.29 (0.19, 0.43)	<0.001	0.32 (0.20, 0.52)	<0.001
Δ24Lac Q4	0.25 (0.16, 0.38)	<0.001	0.14 (0.09, 0.22)	<0.001	0.25 (0.15, 0.43)	<0.001
P for trend		<0.001		<0.001		<0.001
ACLF
Δ24Lac per 10%	0.94 (0.93, 0.96)	<0.001	0.93 (0.91, 0.94)	<0.001	0.93 (0.91, 0.96)	<0.001
Categories
Δ24Lac Q1	Ref	Ref	Ref	Ref	Ref	Ref
Δ24Lac Q2	0.74 (0.51, 1.07)	0.111	0.70 (0.47, 1.03)	0.072	0.58 (0.36, 0.94)	0.026
Δ24Lac Q3	0.37 (0.24, 0.56)	<0.001	0.29 (0.19, 0.45)	<0.001	0.30 (0.17, 0.51)	<0.001
Δ24Lac Q4	0.22 (0.14, 0.35)	<0.001	0.12 (0.07, 0.19)	<0.001	0.19 (0.10, 0.37)	<0.001
P for trend		<0.001		<0.001		<0.001

Model I adjusted for age, sex, LiFe score.

Model II adjusted for age, sex, mean arterial pressure, temperature, 24-hour urine output, albumin, bilirubin, creatinine, INR, vasopressor used, mechanical ventilation, renal replacement therapy.