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. 2019 Jul 12;11(13):4654–4671. doi: 10.18632/aging.102077

Figure 5.

Figure 5

Overexpression of PIR correlates with smoke and early COPD. (A) Detailed heatmap highlights the correlation between the mRNA expression level of PIR and smoke in the GSE4498 cohort (n = 22) using Oncomine online analysis tool. (B) Differential mRNA levels of PIR, FBG, and IL-6 between non-smoker and smoker in the GSE4498 cohort. (C) Detailed heatmaps highlight the correlation between the mRNA expression levels of PIR and non-smoker, smoker, COPD, and early COPD in the GSE5060 cohort (n = 38) using Oncomine online analysis tool. (D) Differential mRNA levels of PIR, FBG, and IL-6 in non-smoker, smoker, COPD, and early COPD in the GSE5060 cohort (n = 38) in the analysis by the Oncomine online analysis tool. (E) The immunohistochemical staining results showed PM-fed mice group had higher concentration of the PIR protein in the lung tissue.