Table 2. Laboratory parameters and levels of middle molecules before and after 12 month treatment with high-flux and medium cut-off dialyzers.
| High-flux HD | MCO HD | |||||
|---|---|---|---|---|---|---|
| Baseline | 12 months | P-value | Baseline | 12 months | P-value | |
| Laboratory parameters | ||||||
| Hemoglobin, g/dL | 10.6 ± 1.5 | 10.3 ± 1.4 | 0.437 | 10.9 ± 1.3 | 10.6 ± 1.1 | 0.314 |
| Platelet, ×106/μL | 155.1 ± 53.1 | 150.1 ± 42.5 | 0.476 | 181.0 ± 57.0 | 182.7 ± 59.3 | 0.805 |
| Total protein, g/dL | 7.05 ± 0.48 | 7.11 ± 0.50 | 0.436 | 6.96 ± 0.49 | 6.96 ± 0.52 | 0.967 |
| Albumin, g/dL | 4.16 ± 0.29 | 4.16 ± 0.30 | 0.932 | 3.96 ± 0.31 | 3.94 ± 0.37 | 0.644 |
| Urea nitrogen, mg/dL | 62.0 ± 22.6 | 59.6 ± 14.6 | 0.684 | 53.5 ± 16.7 | 54.7 ± 16.0 | 0.670 |
| Creatinine, mg/dL | 10.2 ± 3.5 | 10.5 ± 3.4 | 0.425 | 9.7 ± 2.9 | 10.0 ± 2.7 | 0.323 |
| Total calcium, mg/dL | 9.12 ± 0.71 | 9.15 ± 0.70 | 0.781 | 9.17 ± 0.54 | 9.01 ± 0.68 | 0.085 |
| Phosphorus, mg/dL | 4.96 ± 1.82 | 4.65 ± 1.79 | 0.372 | 4.43 ± 1.47 | 4.46 ± 1.74 | 0.847 |
| Sodium, mmol/L | 140.1 ± 1.8 | 138.8 ± 3.7 | 0.204 | 139.7 ± 2.2 | 138.4 ± 2.6 | 0.006 |
| Potassium, mmol/L | 4.92 ± 0.58 | 4.62 ± 0.75 | 0.106 | 5.07 ± 0.78 | 4.73 ± 0.63 | 0.003 |
| Ferritin, ng/mL | 283 (159–562) | 256 (165–529) | 0.891 | 176 (112–388) | 338 (190–555) | 0.007 |
| Transferrin saturation, % | 30.9 (23.9–36.9) | 36.2 (29.3–42.8) | 0.235 | 26.7 (21.7–33.8) | 31.9 (26.8–45.4) | 0.079 |
| Middle molecules | ||||||
| Lambda FLC, mg/L | 154.0 ± 72.3 | 165.9 ± 67.3 | 0.357 | 135.7 ± 39.9 | 132.0 ± 39.1 | 0.543 |
| Kappa FLC, mg/L | 193.3 ± 88.6 | 199.8 ± 79.5 | 0.666 | 168.2 ± 58.5 | 167.7 ± 65.8 | 0.904 |
| β2-microglobulin, mg/L | 27.6 ± 11.3 | 28.6 ± 7.4 | 0.682 | 25.6 ± 9.6 | 28.4 ± 4.8 | 0.046 |
| Vitamin B12, pg/mL | 1127.4 ± 339.4 | 1148.5 ± 297.2 | 0.792 | 1128.5 ± 366.6 | 1118.2 ± 314.9 | 0.890 |
Data are presented as mean ± SD and median (interquartile range), as appropriate. P-values for difference between baseline and 12 months were calculated by paired samples t-test or Wilcoxon signed-rank test, according to the distribution of variables. MCO, medium cut-off; HD, hemodialysis; FLC, free light chain.