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. Author manuscript; available in PMC: 2019 Jul 26.
Published in final edited form as: Gene. 2015 Oct 9;574(2):179–192. doi: 10.1016/j.gene.2015.10.009

Figure 1.

Figure 1.

HFE protein in association with beta-2 microglobulin (β2M) at the cell surface. The three extracellular domains of HFE are designated α1, α2, and α3. β2M is shown associated with the α3 domain. Abbreviations: cyto, cytoplasmic tail; tm, transmembrane domain. Adapted from R.E. Fleming, W. S. Sly, Mechanisms of iron accumulation in hereditary hemochromatosis. Annu Rev Physiol 64 (2002) 663–680. Used with permission.

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