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. Author manuscript; available in PMC: 2019 Jul 26.
Published in final edited form as: Gene. 2015 Oct 9;574(2):179–192. doi: 10.1016/j.gene.2015.10.009

Figure 2.

Figure 2.

A model of regulation of hepcidin transcription by iron. Iron as holotransferrin is shown in orange, iron sensors and associated molecule in gray, bone morphogenic protein (BMP) receptor and its transduction pathway in shades of blue, the ligands and co-receptors of the BMP receptor in shades of green, and the negative regulator protease in purple. *Molecules the ablation of which caused iron dysregulation. Adapted from T. Ganz, Hepcidin and iron regulation, 10 years later, Blood 117 (2011) 4425–4433. Used with permission.

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