Figure 3:

Projection of PDZ2 unbound and bound states and communities using principal component analysis (PCA). (a) Projection of unbound and bond states onto PC1 and PC2 surface; (b-q) Projections of different community pairs onto pair-specific PC1/PC2 surfaces. The unbound and bound states are well separated on PC1/PC2 surface. None of community self-pairs is well separated using PCA. Most different community pairs are well separated using PCA, indicating that the community analysis projects the major part of allosteric effect among different communities.