Table 1.
Percentage inhibition with 0.1 mM of inhibitor using Neu5Acα2–3GalβpNP as the sialidase substrate.
| Sialidases | Neu5Ac2en | 2e3eDFNeu5Ac (1) | 2e3eDFNeu5Ac9N3 (2) | 2e3eDFNeu5N3 (3) | 2e3eDFNeu5Gc (4) | 2e3aDFNeu5Ac (5) | 2e3aDFNeu5Ac9N3 (6) |
|---|---|---|---|---|---|---|---|
| A. ureafaciens | 95.8±0.6 | 99.2±0.3 | 99.9±0.2 | 75.2±0.2 | 96.1±0.6 | 99.9±0.2 | 99.9±0.1 |
| C. perfringens | 72.1±0.0 | 80.6±0.7 | 99.9±0.1 | 29.8±1.2 | 71.6±1.2 | 99.9±0.1 | 99.9±0.1 |
| SpNanA | 94.9±2.2 | 99.7±0.3 | 85.8±0.7 | < 1.0 | 78.4±0.5 | 99.9±0.1 | 99.9 ± 0.1 |
| SpNanB | 2.7±0.3 | 11.8±1.0 | 26.8±0.2 | 35.1±0.8 | 25.3±1.7 | 12.0±0.2 | 16.7±1.6 |
| SpNanC | 6.3±0.6 | < 1.0 | < 1.0 | < 1.0 | < 1.0 | < 1.0 | < 1.0 |
| V. cholerae | 88.2±0.6 | 97.7±0.3 | 99.2±0.5 | 25±1.0 | 97.8±0.1 | 96.8±1.4 | 99.9±0.6 |
| BiNanH2 | 66.7±1.7 | 95.4±0.9 | 98.9±0.0 | 40.8±3.4 | 87.3±0.8 | 98.9±0.5 | 98.8±2.2 |
| PmST1 | 2.1±0.8 | < 1.0 | < 1.0 | < 1.0 | < 1.0 | < 1.0 | < 1.0 |
| hNEU2 | 74.9±0.0 | 75.4±0.6 | 82.3±2.8 | 37.5±1.2 | 80.4±1.3 | 69.7±0.4 | 1.5±0.3 |