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. 2019 Jul 17;6:220. doi: 10.3389/fvets.2019.00220

Table 1.

Example calculation of the mean daily dose and the Canadian defined daily dose for animals (DDDvetCA) for selected antimicrobial active ingredients and routes of administration, in poultry and pigs.

Species Antimicrobial active ingredient ROA a Number of products marketed in Canadab Unique dosages Mean daily dose Feed or water WCRc,d DDDvetCA (mg/kg BW/day)e
Pigs Chlortetracycline Feed 12 55, 110, 220, 656 260.3 mg/kg feed 0.04 10.4
Tylosin Injectable 1 5.5 5.5 mg/kg bodyweight N/Af 5.5
Tylosin Water 2 83, 250 166.5 mg/L water 0.1 16.7
Poultry Bacitracin Feed 3 55, 82.5, 110 77.9 mg/kg feed 0.13 10.1
Amoxicillin Water 2 52 52.0 mg/L water 0.23 12.0
a

Route of administration.

b

Canadian Animal Health Institute (16).

c

WCR, weight conversion ratio in kg feed/kg animal or L water/kg animal.

d

European Medicines Agency (9).

e

BW, body weight.

f

Not applicable.