Table 8.

The ratio of the Canadian defined daily doses for animals (DDDvetCA) by route of administration to the European Medicine Agency's defined daily dose for animals (DDDvet) in pigs.

Antimicrobial active ingredienta	DDDvetCA	Canadian ROA	DDDvetb	EMA ROAc	Ratiod
Amoxicillin	16.0	Water	17.0	Oral	0.9
Ampicillin	20.0e	Water	30.0	Oral	0.7
Ampicillin	6.0	Injectable	12.0	Parenteral	0.5
Apramycin	10.0	Water	9.0	Oral	1.1
Benzathine Penicillin G_combi (LA)	1.2	Injectable	5.4	Parenteral	0.2
Ceftiofur (LA)	1.0	Injectable	0.8	Parenteral	1.3
Ceftiofur	3.0	Injectable	3.0	Parenteral	1.0
Chlortetracycline	10.4	Feed	31.0	Oral	0.3
Enrofloxacin	7.5	Injectable	3.4	Parenteral	2.2
Florifenicol	7.5	Injectable	9.5	Parenteral	0.8
Gentamicin	1.1e	Water	1.4	Oral	0.8
Gentamicin	1.3f	Injectable	1.4	Parenteral	0.9
Lincomycin	5.0	Feed	7.6	Oral	0.7
Lincomycin	10.0	Injectable	10.0	Parenteral	1.0
Lincomycin	3.3	Water	7.6	Oral	0.4
Lincomycin_spectinomycin	0.9	Feed	2.2	Oral	0.4
Lincomycin_spectinomycin	2.2	Water	2.2	Oral	1.0
Neomycin	19.7f	Bolus	25.0	Oral	0.8
Neomycin	12.5	Water	25.0	Oral	0.5
Oxytetracycline	26.2f	Bolus	26.0	Oral	1.0
Oxytetracycline	14.6f	Injectable	7.5	Parenteral	1.9
Oxytetracycline	7.6	Feed	26.0	Oral	0.3
Oxytetracycline	5.9	Injectable	7.5	Parenteral	0.8
Oxytetracycline	14.6	Water	26.0	Oral	0.6
Penicillin G	1.3	Feed	48.0	Oral	<0.1
Penicillin G	17.8	Water	48.0	Oral	0.4
Procaine Penicillin G	13.5	Injectable	13.0	Parenteral	1.0
Spectinomycin	18.8f	Bolus	33.0	Oral	0.6
Spectinomycin_lincomycin	0.9	Feed	3.4	Oral	0.3
Spectinomycin_lincomycin	4.5	Water	3.4	Oral	1.3
Sulfadiazine_trimethorprim	32.4e	Water	23.0	Oral	1.4
Sulfadoxine_trimethoprim	13.6f	Injectable	14.0	Oral	1.0
Sulfaguanidine	83.8f	Bolus	54.0	Oral	1.6
Sulfamethazine	118.1f	Bolus	92.0	Oral	1.3
Sulfamethazine	4.4	Feed	92.0	Oral	<0.1
Sulfamethazine	79.0	Water	92.0	Oral	0.9
Tetracycline	15.3f	Bolus	49.0	Oral	0.3
Tetracycline	8.6	Water	49.0	Oral	0.2
Tiamulin	5.7	Feed	9.7	Oral	0.6
Tiamulin	11.0	Injectable	12.0	Parenteral	0.9
Tiamulin	4.9	Water	9.7	Oral	0.5
Tilmicosin	10.0e	Water	15.0	Oral	0.7
Tilmicosin	12.0	Feed	15.0	Oral	0.8
Trimethoprim_sulfadiazine	7.1	Water	4.7	Oral	1.5
Trimethoprim_sulfadoxine	5.0f	Injectable	4.7	Parenteral	1.1
Trimethoprim_sulfadoxine	2.4	Injectable	3.0	Parenteral	0.8
Tylosin	3.1	Feed	12.0	Oral	0.3
Tylosin	5.5	Injectable	13.0	Parenteral	0.4
Tylosin	16.7	Water	12.0	Oral	1.4
Tylvalosin	1.7	Feed	3.6	Oral	0.5
Tylvalosin	5.0	Water	3.6	Oral	1.4

Ratios above 1.5 and below 0.5, indicating substantial differences in these standardized doses, are in bold print.

^aAntimicrobial active ingredients written as: Active ingredient 1_active ingredient 2 = DDDvetCA for active ingredient 1 when used in combination with active ingredient 2.

^bEuropean Medicines Agency. Defined daily doses for animals (DDDvet) and defined course doses for animals (DCDvet). 2016.

^cThe EMA combined in-feed, in-water and oral bolus routes of administration into one oral DDDvet.

^dRatio = DDDvetCA/DDDvet.

^eDDDvetCA assigned using compounded doses.

^fDDDvetCA assigned using young animal doses.