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. 2019 Jul 16;10:752. doi: 10.3389/fneur.2019.00752

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Copyright © 2019 Yang, Lin, Li, Han, Li, Liu, Hou, Xie, Lv and Qiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ReHo changes among the three time points compared with a whole-brain voxel-wise based one-way repeated measure ANOVA and post-hoc tests. There were three patterns of dynamic change for the ReHo index: “increase-decrease-recover” pattern (A–C), with full-recovery in the right cerebellum (A) and right ITGs (B), and with partial-recovery in the left cerebellum (C); “increase” pattern without significant recovery in the right TPOmid (D); “decrease” pattern without significant recovery in the left insula (E). Brain regions were reported at the significant level of a threshold of two-tailed voxel-wise P < 0.01 and cluster level P < 0.05 with Gaussian Random Field correction. Error bars indicate two standard errors, and pentagrams indicate significant differences revealed by ANOVA post-hoc tests with Dunnett's tests (P < 0.05). ANOVA, analysis of variance; EDS, early-delayed stage; L, left; LDS, late-delayed stage; ITG, inferior temporal gyrus; MNI, Montreal Neurological Institute; R, right; ReHo, regional homogeneity; TPOmid, temporal pole: middle temporal gyrus; RT, radiotherapy.