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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: J Cell Physiol. 2019 Apr 5;234(11):20228–20239. doi: 10.1002/jcp.28623

Figure 4: Overexpression of Noct WT showed no significant changes in both trabecular and cortical bone at 16 weeks with Dox treatment.

Figure 4:

Noct WT mice were treated with either Sacch or Dox beginning at 4 weeks of age and followed till 16 weeks of age. A) Areal Bone mineral density (aBMD) was measured by DXA at 8, 12 and 16 weeks (n=6–12). B) Representative μCT images of trabecular bone (Tb); followed by femoral microarchitecture trabecular parameters measured at 16 weeks. Tb. BV/TV, Tb.Th, Tb.N, Tb.Sp and Conn.D. C) Representative μCT images of cortical bone (Ct.) and femoral microarchitecture cortical parameters measured Ct.Ar/Tt.Ar, Ct.Ar, Tt.Ar, Ma.Ar, Ct.Porosity, Ct.Th and Ct.TMD are shown. Values represent mean ± SEM of n=4–5. p values are calculated as described in methods section for A and using an unpaired students t-test in GraphPad Prism for B,C.