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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Brain Behav Immun. 2019 Feb 23;80:73–87. doi: 10.1016/j.bbi.2019.02.024

Figure 1.

Figure 1.

SCI induces upregulation of NOX2 expression predominantly in microglia/macrophages. (A-B) NOX2 elevation in injured spinal cord tissue. n=3–6 mice/group. *p<0.05, ***p<0.001 vs Sham. (C) At 24h after SCI, NOX2 expression by Iba-1+ microglia/macrophages at the lesion core. Scale bar = 25 μm. (D) NOX2+/Iba-1+ cells are significantly increased (3 fold) at the lesion site from 8 weeks SCI mice. N=5 mice/group. **p<0.01 vs Sham. (E) Representative images for NOX2+/Iba-1+ cells in the dorsal white matter at 0.2 mm rostral to the epicenter from Sham and 8 weeks SCI mice. Scale bar = 50 μm. Insets display high magnification images.