Table 2.

Vascular Parameters

	Spironolactone n=28			Placebo n=32
	BL	24 wk	Δ	BL	24 wk	Δ	P-Value
Brachial artery FMD
percent change	8.0±5.5	7.8±4.3	−0.2±3.2	8.4±6.2	8.0±4.6	−0.4±4.7	0.9
absolute change; mm	0.26±0.16	0.26±0.12	−0.00±0.11	0.26±0.14	0.25±0.13	−0.01±0.13	0.8
Baseline brachial artery diameter (mm)	3.6±0.7	3.6±0.6	−0.1±0.2	3.4±0.6	3.3±0.6	−0.0±0.2	0.5
Peak shear rate (s−1)	1009±424	1100±336	91±329	1121±489	1174±426	54±410	0.7
Brachial artery dilation to nitroglycerin
percent change *	27.9±9.1	28.6±6.8	0.7±4.4	28.0±6.1	28.9±7.3	0.9±7.4	0.9
absolute change; mm *	0.94±0.22	0.97±0.19	0.03±0.12	0.95±0.21	0.94±0.17	−0.01±0.19	0.5
Brachial SBP (mmHg)	124±13	117±11	−6 (−15, 1)	124±10	125±13	−2 (−7, 10)	0.04
Brachial DBP (mmHg)	74±10	70±9	−4 (−10, 3)	75±9	75±10	−1 (−7, 9)	0.2
Carotid-femoral PWV (cm/s)	640±125	603±101	−37±78	659±138	658±131	−1±89	0.1
Carotid-radial PWV (cm/s)	924±126	903±147	−21±106	920±185	937±187	18±188	0.3
Carotid intimal medial thickness (mm)	0.48±0.09	0.48±0.09	−0.01±0.05	0.47±0.07	0.47±0.06	−0.00±0.07	0.7
Carotid augmentation index (%)	9.3±15.0	2.5±16.5	−6.8±14.6	8.3±15.4	13.4±14.1	5.2±13.3	0.002
Carotid artery compliance (mm/mm Hg * 10−1)	0.12±0.04	0.12±0.04	0.01±0.02	0.12±0.04	0.12±0.03	0.00±0.03	0.5
Carotid β-stiffness index (A.U.)	6.1±2.0	5.8±1.7	−0.3±1.3	6.0±2.1	5.8±2.1	−0.2±1.9	0.7
Carotid SBP (mmHg)	118±15	110±12	−8±15	120±15	120±16	0±17	0.06

Data are mean±S.D or median [IQR]. P-value is a comparison of the change from baseline to 24 weeks (Δ) between the 2 groups using a t-test for normally distributed variables and a non-parametric (Wilcoxon rank sums) test for non-normally distributed variables. Blood pressures were taken in the supine position. BL, baseline; FMD, flow-mediated dilation; NTG, nitroglycerin; SBP, systolic blood pressure; DBP, diastolic blood pressure; PWV, pulse-wave velocity.

^*N=16 for spironolactone and n=15 for placebo for NTG variables.