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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Brain Behav Immun. 2019 May 24;80:839–848. doi: 10.1016/j.bbi.2019.05.034

Figure 4.

Figure 4.

C/EBPβ regulation of M2 and M1 genes modulated by β-adrenergic signaling in RAW 264.7 cells. (A) Isoproterenol up-regulated M2 genes that were suppressed by C/EBPβ inhibition in global gene expression profiles; red = up-regulation and blue = down-regulation, as mean fold change from control group fixed at 0 on log2 scale for each given gene. (B) TELiS differential expression analysis of transcription factor binding motif prevalence for C/EBPβ in M2 genes from panel A. (C) Isoproterenol down-regulated M1 genes that were rescued by C/EBPβ inhibition in global gene expression profiles. (D) TELiS differential expression analysis of transcription factor binding motif prevalence for C/EBPβ in M1 genes from panel B. *** P < 0.001 vs. reference genome.