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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: J Cell Physiol. 2019 Apr 2;234(11):19121–19129. doi: 10.1002/jcp.28603

Figure 1. TXA suppresses the spontaneous and induced mtDNA release from HL60 granulocytes, and spontaneous mtDNA from HUVEC.

Figure 1

A) Differentiated HL60 granulocytes were incubated for 24 h with or without 20 or 100 μg/ml TXA. Cells were centrifuged, and released mtDNA in the supernatant was determined by qPCR using specific primers to human mtDNA. Mean mtDNA release levels normalized to untreated control, with standard deviations are shown. B) HL60 granulocytes were incubated for 4 h in presence of 0.3 μg/ml mouse mtDNA, with or without 100 μg/ml TXA, released mtDNA was determined. C) HUVEC were incubated for 4 h with or without 20 or 100 μg/ml TXA, released mtDNA was determined. D) HUVEC were incubated for 4 h in presence of 0.3 μg/ml mouse mtDNA, released mtDNA was determined.