Before learning and memory testing, wild-type (WT) and Tg26(+/−) mice were screened for any morphological, sensorimotor, and reflexive differences. Male mice had a larger body mass than female mice (A), yet only female Tg26(+/−) mice had diminished body length (B) when compared to their female WT littermates. Defecation incidence (C), touch escape responses (D), and toe pinch responses (E) remained similar, between genotype and biological sex. Data is presented as the Mean ± SEM from 8 to 11 mice per genotype/sex. ** p < 0.01 indicates significant decrease compared to corresponding WT littermate. + p < 0.05 and ++ p < 0.01 indicate significant changes compared to the corresponding males.