Table 3. The Odds Ratio of Hemorrhage according to Small Vessel Disease Imaging Markers by Multiple Logistic Regression Analysis.
| Variables | Model 1* OR (95% CI) | Model 2† OR (95% CI) | Model 3‡ OR (95% CI) |
|---|---|---|---|
| Presence of CMB | 31.163 (18.015–53.906) | 33.149 (17.574–62.529) | 15.089 (7.253–31.391) |
| WMH periventricular | |||
| Grade 0, I (Ref) | 1 | 1 | 1 |
| Grade II, III | 13.975 (8.071–24.198) | 31.623 (13.933–71.771) | 5.532 (1.541–19.856) |
| WMH deep white matter | |||
| Grade 0, I (Ref) | 1 | 1 | 1 |
| Grade II, III | 10.499 (6.156–17.905) | 18.580 (8.759–39.413) | 1.271 (0.353–4.574) |
| EPVS basal ganglia | |||
| Grade 0, I (Ref) | 1 | 1 | 1 |
| Grade II, III | 8.472 (5.382–13.335) | 12.051 (6.661–21.801) | 4.227 (1.676–10.656) |
| EPVS centrum semiovale | |||
| Grade 0, I (Ref) | 1 | 1 | 1 |
| Grade II, III | 5.806 (3.756–8.976) | 6.129 (3.668–10.242) | 1.301 (0.562–3.011) |
| Presence of lacunae | 8.087 (5.023–13.018) | 9.190 (5.088–16.600) | 1.570 (0.651–3.785) |
OR, odds ratio; CI, confidence interval; CMB, cerebral microbleeds; WMH, white matter hyperintensity; Ref, reference; EPVS, enlarged perivascular space.
*Unadjusted analysis; †Adjusted for clinical variables: age, sex, hypertension, diabetes, high density lipoprotein cholesterol and low density lipoprotein cholesterol; ‡Adjusted for clinical variables and all imaging markers.