Table 4. Comparison of Sensitivity and Specificity of Serum ADAM 8, CEA and Their Combination as Single Markers and/or as a Multiple-Markers Panel for Prediction of GC Determined by Logistic Regression Analysis in Validation Dataset.

Marker panel*	Cut-off values	Sensitivity (%)	Specificity (%)
ADAM 8	30	73.7	86.2
CEA	5	23.1	91.4
ADAM 8+CEA	25, 5	81.8	84.0

ADAM 8, a disintegrin and metalloproteinase domain 8; CEA, carcinoembryonic antigen; GC, gastric cancer.

^*Each marker was included as a linear term and evaluated as part of a panel of one to two markers in combination.