Fig. 3.

AD pedigrees reported to demonstrate potential segregation of ABCA7 PTC (a) or missense (b) variants. Individuals are represented by diamonds, annotated according to their disease status: AD (black), MCI or suggestive cognitive decline (gray), Parkinson disease (diamond with dot), unaffected at the time of examination (white), and unknown (question mark). Striked through diamonds correspond to deceased individuals, numbers depict the age at onset, or age at examination (marked with #). PTC = this individual carries the PTC variant. Missense = this individual carries the missense variant. DNA = this individual had DNA available and was screened for carriership of the variant