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. 2018 Jun 25;26(4):1064–1075. doi: 10.1007/s12350-018-1325-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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¹⁸F-NaF microPET and microCT images of human carotid plaque. (A, E) Human carotid plaque after carotid endarterectomy. (B, F) Sagittal view of ex vivo PET showing a heterogeneous distribution of ¹⁸F-NaF uptake with a clear hotspot (red/yellow). (C, G) Sagittal view of corresponding microCT images. On the background of example G are the contours of the CT bed visible. (D, H) Fused images showing different distributions of microcalcification (¹⁸F-NaF PET) and established calcification (microCT). Scale PET images in %Inc/g, scale CT images in HU