Fig. 2.

Blood of LGG patients do not harbor CD4 T cell reactivity against IDH1^R132H. PBMCs from patients with IDH1^R132H-positive gliomas were directly stimulated with IDH1^R132H or IDH1^WT peptide for 16 h (n = 30 patients). a Percentage of CD137+ cells within CD4+ T cells. b IFN-γ response of the same T cell populations as in (a). Each dot represents an individual patient sample. MOG, IDH1^WT, and IDH1^R132H were corrected for the medium values. Medium, no peptide, negative control. SEB, staphylococcus-derived enterotoxin B, positive control. MOG, myelin oligodendrocyte glycoprotein peptide, negative control