Fig. 4.

Lack of galectin-3 reduces AD pathology in 5xFAD mice. Aβ load in hippocampus (CA1) and thalamus at 6 months (a) and 18 months (b) with Aβ load analyzed in 5xFAD and 5xFAD/Gal3KO mice (% in frames). Soluble fractions of Αβ40 and Αβ42 levels in cortical S1 fraction were measured (pg/ml). c Αβ40 and Αβ42 levels in CSF samples at 6 months (pg/mL). d IDE-1 levels in 5xFAD and 5xFAD/Gal3KO mice at 6 and 18 months. e Spatial memory analyzed by Morris water maze test. Center, distance traveled (meters) as an integrated distance (AUC area under the curve). Left, latency to the platform during training trials. Right, representative runs of probe trial day. Q1, quadrant where the platform was located on training trial. Statistical significance was calculated by two-way (with Bonferroni’s post hoc) (e) and Student’s t-test (a–e). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Data are shown as mean ± SEM