The HOXC gene cluster displays predominantly atherosclerosis-associatedDNA hypermethylation in half of the cluster and athero hypomethylation in the other half. (A) RefSeq gene isoforms and chromatin state segmentation (chr12:54,326,508-54,452,368). (B) Tissue-specific and atherosclerosis-associated DMRs. (C) Bisulfite-seq DNA methylation profiles. Yellow highlighting with black dot underneath in the DMR tracks, athero DMRs with PMD <40% (strongly hypomethylated). Note that there are regions of low leukocyte DNA methylation that overlap athero hypermeth DMRs and, therefore, monocyte infiltration could not explain these DMRs.