Table 1.

Proteins identified using MS after IP against αSN from the human CSF

Sample	log(e)	log(I)	PCM	PCC	UP	MW	Description
CSF IP	−188.3	7.05	52	67	14	36.1	APOE:p, apolipoprotein E
	−141	5.62	71	82	11	11.4	SNCA:p, synuclein alpha
	−132.1	5.28	18	21	10	69.2	Serum albumin, bovine; BSA
	−104.2	6.84	35	44	9	30.8	APOA1:p, apolipoprotein A1
	−43.9	7	12	29	4	52.5	ApoJ:p, apolipoprotein J
	−20.2	4.8	12	15	2	24.4	Trypsin; EC 3.4.21.4
	−14.8	4	24	33	2	12.6	IGHV@:p, Ig heavy variable 3-23
Negative control IP	−52	4.47	8.8	16	5	41.3	Ig heavy constant gamma 3
	−4.7	4.11	4.7	7	1	24.5	Bovine Alpha-S1-casein
	−4.6	3.28	2.6	4	1	36.6	IGHA2:p, Ig heavy constant α 2
Positive control Recombinant αSN IP	−145	5.15	71	82	11	11.4	SNCA:p, synuclein alpha
	−15.1	3.76	24	33	2	12.6	IGHV@:p, Ig heavy variable 3-23

Proteins identified in CSF samples, a specificity control, i.e., the sample without the αSN antibody and a positive control, i.e., samples spiked with recombinant αSN; log(e), base-10 log of the expectation that this assignment is stochastic; log(I), base-10 log of the sum of the intensities of the fragment ion spectra; PCM, protein coverage measured; PCC, protein coverage corrected; UP, number of unique peptides found; MW, molecular weight (kilodaltons).