Table 1.
Major characteristics of included studies
| Author | Year | Tp | Fp | Fn | Tn | Country | Ethnicity | Type of study | Etiology | Reference image | Type of CNV | Device |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Moult E | 2014 | 16 | 0 | 1 | 63 | USA | Caucasian | Prospective | AMD | FA,ICGA | NA | VCSEL |
| Lupidi M | 2015 | 4 | 0 | 1 | 20 | France | Caucasian | Retrospective | AOFVD | FA,ICGA,OCT | NA | Spectralis |
| Bonini Filho MA | 2015 | 8 | 0 | 0 | 19 | USA | Mixed | Prospective | CSCR | FA | Type1, mixed type 1/2 | AngioVue |
| de Carlo TE | 2015 | 4 | 2 | 4 | 20 | USA | Mixed | Retrospective | Multiple1 | FA | NA | AngioVue |
| Shaimov TB | 2015 | 33 | 1 | 4 | 14 | Russia | Caucasian | Prospective | AMD | FA | Type1,2 | AngioVue |
| Carnevali A | 2016 | 18 | 0 | 4 | 22 | Italy | Caucasian | NA | AMD | ICGA | NA | AngioPlex/ Angiovue |
| Miyata M | 2016 | 16 | 0 | 1 | 4 | Japan | Asian | NA | Myopia | FA | Type 2 | AngioVue |
| de Carlo TE | 2016 | 6 | 1 | 1 | 22 | USA | Caucasian | Retrospective | CSCR | FA | NA | AngioVue |
| Gong J | 2016 | 45 | 11 | 7 | 23 | China | Asian | Retrospective | AMD | FA | Type1,2,mixed type1/2 | AngioVue |
| Querques L | 2017 | 19 | 2 | 2 | 30 | Italy | Caucasian | Retrospective | Myopia | FA,OCT | NA | AngioPlex |
| Faridi A | 2017 | 32 | 0 | 0 | 40 | USA | Caucasian | Prospective | AMD | FA,OCT | NA | AngioVue |
| Ahmed D | 2018 | 81 | 0 | 26 | 49 | Austria | Caucasian | Retrospective | AMD | FA | Type1,2,3,mixed type | Topcon |
| Nikolopoulou E | 2018 | 44 | 2 | 6 | 18 | Italy | Caucasian | Prospective | AMD | FA | Type1,2,3,mixed type1/2 | AngioVue |
| Souedan V | 2018 | 8 | 1 | 1 | 6 | France | Caucasian | Retrospective | Multiple2 | FA,OCT | All types | AngioVue |
| Soomro T | 2018 | 32 | 6 | 13 | 26 | England | Caucasian | Retrospective | Multiple3 | FA | Type1,2 | Spectralis |
| de Oliveira T | 2019 | 9 | 0 | 1 | 12 | Brazil | Mixed | NA | Multiple4 | FA,ICGA,OCT | NA | AngioVue |
Tn True positive, Fp False positive, Fn False negative, Tn True negative, AMD Age-related macular degeneration, AOFVD Adult onset foveomacular vitelliform dystrophy, CSCR Central serous chorioretinopathy, FA Fluorescein angiography, ICGA Indocyanine green angiography, OCT Optical coherence tomography, CNV Choroidal neovascularization
Multiple1 = AMD, CSCR and different diagnosis (angioid streaks, multifocal choroiditis, myopic degeneration, pars planitis, or an unclear diagnosis with the differential diagnosis including CSCR, neo-vascular AMD, or polypoidal choroidal vasculopathy (PCV)
Multiple2 = AMD, reperfused central retinal artery obstruction, one adult onset pseudovitelliform lesion, drusenoid pigment epithelium detachment, CSCR, macroaneurysm and reticular dystrophy
Multiple3 = AMD, PCV, CSCR or pathological myopia
Multiple4 = AMD, PCV and CSCR
VCSEL = OCTA combining vertical cavity surface emitting laser (VCSEL) swept light source OCT with 400 kHz A-scan rate prototype system
Topcon = Topcon OCT-A (Topcon Corporation, Tokyo, Japan)
AngioVue = AngioVue OCT-A (Optovue, Inc., Freemont, CA)
AngioPlex = AngioPlex OCT-A (Carl Zeiss Meditec, Inc., Dublin, USA)
Spectralis = Spectralis OCT-A (Heidelberg Engineering, Heidelberg, Germany)
NA = Not available