Table 2.

Meta-regression and subgroup analyses for sensitivity and specificity

Covariate	Number of studies	Number of eyes	Sensitivity (95% CI)	P-value	Specificity (95% CI)	P-value
Ethnicity
Asian	2	107	0.91 (0.80–1.00)	0.69	0.82 (0.53–1.00)	0.09
Other races	14	754	0.87 (0.80–0.93)		0.97 (0.95–1.00)
Type of study
Prospective	5	301	0.93 (0.88–0.98)	0.61	0.99 (0.96–1.00)	0.08
Retrospective	8	473	0.79 (0.72–0.86)		0.93 (0.87–1.00)
Etiology
AMD	7	560	0.89 (0.82–0.95)	0.12	0.98 (0.94–1.00)	0.44
Other ocular diseases	9	301	0.85 (0.76–0.94)		0.97 (0.92–1.00)
Reference standard
FA	9	549	0.83 (0.76–0.90)	< 0.01	0.94 (0.88–1.00)	0.09
Other reference standards	7	372	0.92 (0.86–0.97)		0.99 (0.97–1.00)
Type of device
AngioVue	10	426	0.90 (0.86–0.95)	0.09	0.96 (0.91–1.00)	0.66
other devices	6	435	0.80 (0.72–0.87)		0.98 (0.96–1.00)
Sample size
≥ 50	8	690	0.88 (0.81–0.95)	0.12	0.96 (0.91–1.00)	0.57
< 50	8	171	0.86 (0.77–0.96)		0.99 (0.96–1.00)