. 2019 Jul 26;12:369. doi: 10.1186/s13071-019-3632-3

Table 1.

Laboratory study design and efficacy of ProHeart® 12 against Dirofilaria immitis in dogs

Group^a (n = 10)	Treatment	Dosage (mg/kg)	Day of treatment	No. of dogs with worms	Adult D. immitis worm counts^b
Group^a (n = 10)	Treatment	Dosage (mg/kg)	Day of treatment	No. of dogs with worms	Individual worm counts	Geometric mean	Percentage reduction
Study 1
T01	Vehicle	0	0	10	22, 25, 29, 30, 30, 31, 32, 34, 35, 37	30.2	–
T02	ProHeart® 12 (moxidectin)	0.5	0	0	0	0^c	100
Study 2
T01	Vehicle	0	0	10	22, 28, 30, 32, 32, 33, 34, 36, 40, 44	32.6	–
T02^d	ProHeart® 12 (moxidectin)	0.5	0	0	0	0^e	100

^aAll dogs were inoculated with 50 D. immitis L₃ on Day 365. Study 1, D. immitis ZoeAL-01-2015; Study 2, D. immitis GCFL-01-2014

^bAll dogs were necropsied for recovery and enumeration of adult HWs on Day 517 (Study 1) or Day 519 (Study 2)

^cGeometric mean is statistically different from that of Group T01 (P < 0.0001)

^dn = 9 for Group T02 in Study 2; one dog was excluded from study due to incomplete dosing. n = 10 for all other groups

^eGeometric mean is statistically different from that of Group T01 (P < 0.0112)