Table 3.
Results from clinical field study on efficacy of ProHeart® 12 against Dirofilaria immitis in dogs
| Treatment group | Study day | Adult HW antigen test | Microfilaria test | Total no. of dogs | Prevention rate (Day 365) |
Prevention rate (Day 480) |
Prevention rate (Day 605) |
Overall prevention rate | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Negative | Positive | Negative | Positive | |||||||||||
| No. of dogs | % | No. of dogs | % | No. of dogs | % | No. of dogs | % | |||||||
| Heartgard® Plus (T01) | 365 | 215 | 98.6 | 3 | 1.4 | 216 | 99.1 | 2 | 0.9 | 218a | 98.6% (215 of 218) | 99.5% (208 of 209) | 100% (201 of 201) | 98.2% (214 of 218) |
| 480 | 208 | 99.5 | 1 | 0.5 | 208 | 99.5 | 1 | 0.5 | 209b | |||||
| 605 | 201 | 100 | 0 | 0 | 201 | 100 | 0 | 0 | 201 | |||||
| ProHeart® 12 (T02) | 365 | 235 | 100 | 0 | 0 | 235 | 100 | 0 | 0 | 235 | 100% (235 of 235) | 100% (226 of 226) | 100 (222 of 222) | 100%c (235 of 235) |
| 480 | 226 | 100 | 0 | 0 | 226 | 100 | 0 | 0 | 226 | |||||
| 605 | 222 | 100 | 0 | 0 | 222 | 100 | 0 | 0 | 222 | |||||
aThree dogs (treated with Heartgard® Plus) were withdrawn after testing positive for adult HW antigen and/or microfilariae on Day 365
bOne dog (treated with Heartgard® Plus) was withdrawn after testing positive for adult HW antigen and/or microfilariae on Day 480
cProHeart® 12 significantly better than Heartgard® Plus (P = 0.0367)