Fig. 3.

Analyses of SL interactions of FBXW7. a TCGA gene expression of FBXW7 in 24 cancer types and corresponding normal tissue as calculated from RNA-seq data by expectation-maximization (log₂). The averages of normal and tumor expression of FBXW7 for the same tissue type are plotted beside each other and colour-coded based on cancer type. Numbers of patient samples are indicated in the x-axis labels. b Box plot classifying multiple cell lines from the cancerRXgene database based on the expression of FBXW7; up-regulated (red) and down-regulated (blue). c-d Drug kill curves for cell lines where FBXW7 is down-regulated in blue, and cell lines that have up-regulated FBXW7 in red. c Drug curves for Cabozantinib, and (d) Selumetinib