Skip to main content
. Author manuscript; available in PMC: 2020 Feb 28.
Published in final edited form as: J Control Release. 2019 Jan 5;296:1–13. doi: 10.1016/j.jconrel.2019.01.004

Figure 1.

Figure 1

Sodium bicarbonate nanoparticles. Liposomes encapsulating sodium bicarbonate were constructed of HSPC, cholesterol and PEG-DSPE at 50mM total lipid concentration (A) having a mean diameter of 103nm (B), and a zeta potential of -7.37mV (A). The intra-liposomal pH was 7.8±0.02, measured using a pyranine indicator (C-D). Intra-liposomal pH measurements over time showed stable values over one week (25 °C). (E steps1-3) Direct pH measurements of the aqueous phase after being extracted during the liposome formulation process. (E step4) Normalized pH of the aqueous phase after Bligh and Dyer phase separation.