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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Hum Mutat. 2019 Apr 1;40(7):962–974. doi: 10.1002/humu.23745

Figure 1: Calcium homeostasis and ECC are affected by the presence of SELENON mutations.

Figure 1:

A. Depolarization (KCl) dose response curve; controls, black squares continuous line; patient N° 17, open squares dashed line; patient N°18, open circles, dotted line. B 4-chloro-m-cresol dose response curve; controls, black squares continuous line; patient N° 17, open squares dashed line; patient N°18, open circles dotted line C. Representative traces showing changes in [Ca2+]i induced by stimulation with 60 mM KCl. Continuous line, control; dashed line, patient N°17. D. Representative trace showing changes in [Ca2+]i induced by stimulation with 600 µM 4-chloro-m-cresol. Continuous line, control; dashed line patient N° 17; dotted line patient N° 18. In panels A and B, each symbol represents the mean (±SEM) peak calcium released by 5-10 myotubes.